Protein Small Molecule Interactions
Research and development of protein arrays and their applications in proteomics
Explore interaction profiles and identify off-target binding.
HuProt™ arrays can also be employed to determine near proteome-wide interaction profiles of small molecules, such as drug candidates. The microarray allows the rapid generation of binding profiles.
Read-out of the HuProt microarrays is by fluorescence, hence a fluorescent label needs to be conferred on the small molecule of interest. Options include:
Zhang HN et al (2015). Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci U.S.A. 112(49):15084-9