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Research and development of protein arrays and their applications in proteomics

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Autoantibody Screening

 

HuProt™ application: Autoantibody screening in serum samples

Discover autoimmune antigens, delineate new candidate biomarkers.

 

Autoantibodies, leading to immune reactivity against specific tissues, are the cause of autoimmune diseases. Indentifying which antigens are the target of autoantibodies can be the first step to understanding the underlying disease mechanisms, as well as to disease stratification. Because of their uniquely broad content of human proteins, HuProt™ arrays present a strategy for uncovering the identity of as yet unknown autoantigens, or for the initial characterisation of conditions of suspected autoimmune aetiology.


Autoantibodies have also gained prominence as early diagnostic biomarkers in cancer, where they may emerge as an effect, rather than as the cause of the disease. HuProt™ arrays provide the option to discover and identify signature autoantibodies through interaction with their arrayed antigens.
 

Assay Format

 

Typically, diluted serum is incubated on the HuProt array, followed by secondary detection with a fluorophore-labelled anti-human Ig reagent.  

 

References

 

GET IN TOUCH

 

Contact us to discuss how your screening project can benefit from using HuProt v3.0 arrays.

 

+44 (0)1223 496557

info@cambridgeproteinarrays.com